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These solutions do not work for fluorescence microscopy because fluorescence light is not coherent, meaning that there is no time-distance relationship between the excitation light and the fluorescence emission. Imec’s Niels Verellen.imec’s lens-free microscope, for example, uses the interference pattern of the excitation light to reconstruct the image holographically. Lens-free options exist for light microscopy, where the viewer looks directly at the scattered light. To downsize the microscope, Verellen’s team removed the key part of standard optical microscopes: the lens. At the halfway point of the five-year project, he has just described on the imec website the early successes and remaining challenges. Niels Verellen, Principal Scientist at imec, has received an ERC Starting Grant to design a high-resolution microscope on-chip with a scalable field of view. The scaling possibilities could allow chip-microscopes to be produced at a fraction of the cost of standard devices, says a research group at imec, the Belgium-based nanotechnology and photonics research center. For scientists to see more detail, larger optical components are required, but this causes the field of view to decrease.Ĭhip technology offers a different view: chips are compact and can integrate multiple functionalities. Concept of fluorescence microscope on chip illumination spots are generated in the photonic circuit.Conventional light microscopy has been instrumental for the study of cells and microorganisms fluorescence microscopy has enabled visualization of even smaller cell features by selectively adding fluorescent labels to molecules.īut fluoresence microscopes are often bulky and expensive systems that require regular maintenance to keep the lenses aligned.